Office Hours: Sundays 9:30 – 10:20
Tuesdays 9:30 – 10:20
Assistants: To be announced
Course Sched.: Saturdays hh:mm – hh:mm Room # Barghx
Mondays hh:mm – hh:mm Room # Bargh x
Prerequisites: Biosensors or equivalents
Course Description: This course provides a short review on the principles of biosensors and general types, providing an introduction into the most common biosensing principles, and introducing biosensors as reliable devices for a vast variety of applications, which is constantly improving the detection speed and the specificity. This would be an overview of biosensors including also biological/biomedical microelectromechanical systems and bioanalytical devices with an introduction to fundamental principles, and detection methods.
The considered biosensors in this course use a bio-chemical/physical process as a signal transduction mechanism to produce an electrical signal that can be used to perform point-of care diagnostics. This course also gives background information on the underlying theories as well as the current limitations of the biosensing technologies. Besides covering the sensing principle itself, the course will go into details on the fabrication aspects, stressing on how microfabrication can be used to miniaturize some of these devices. Moreover, the course will cover considered emerging biosensor.
- Introduction: What makes up a biosensor, and different types of classification of biosensors, as well as biosensor performance metrics.
- Biochemical recognition elements.
- Electrical Amperometric Biosensors.
- Electrical Potentiometric Biosensors.
- Electrochemical impedance spectroscopy based biosensors.
- Cyclic Voltammetry, Diffusion-controlled current.
- The ISFET – an integrated potentiometric biosensor.
- Conducting polymer-based FETs structure.
- Cells and ISFETs as biosensors.
- Review of Principles of optical biosensors.
- Optrode-based fiber optic biosensors.
- Use of Surface Plasmon Resonance in optical biosensors.
- Plasmonic SERS molecular sentinels.
- Fluorescence-based biosensing.
- Chemiluminescence based Optical biosensing.
- Microfluidic chip based biosensors.
- Nanoparticles for biosensors.
- Introduction to operation principles of SQUIDs.
- SQUID based MCG and MEG.
References: Lecture notes – Cell-Based Biosensors: Principles and Applications, By Ping Wang & Qingjun Liu, 2010. – Biosensors: An introduction, By Brian R. Eggins, R. Wiley , 1996. – Biosensors, by Elizabeth A. H. Hall, 1990. – Biosensors, By Tran Minh Canh, Chapman & Hall 1993. – Chemical sensors and biosensors, by Brian R. Eggins, John Wiley , 2002. – Medical Instrumentation Application and Design, 4th Ed, by John G. Webster, Wiley, 2011. – Handbook of Modern Sensors – Physics, Designs, and Applications, 3rd Edition, By Jacob Fraden, Springer 2003. – OPTICAL BIOSENSORS:Today and Tomorrow, Edited by FRANCES S LIGLER and CHRIS ROWE TAITT, 2nd edition, Elsevier 2008.
Grading: HWs & Quizzes: 12%
Final Exam: 40%